Wireframe Ventures is a seed-stage venture capital fund built around a "people-product-purpose" thesis that only backs founders whose mission to improve the health of people and planet is inseparable from their commercial product, focusing on climate and human health since 2016 when few early-stage investors had domain experience in these areas. The fund has demonstrated strong performance by taking early technical risk in deeptech, biotech, and energy companies before these categories became mainstream, with Fund I's 25 investments leading to two unicorns, two exits, and ~70% of portfolio companies raising institutional Series A rounds within 15 months.