Andrea Turner Moffitt co-founded Plum Alley Investments based on multi-year global research she conducted with the Center for Talent Innovation and six major wealth management firms, which quantified women's decision-making power over investable assets and segmented women investors rather than treating them as a monolith. She built Plum Alley specifically to provide access for underrepresented investors to later-stage private company deals (Series A, $3–10M rounds) rather than typical very-early-stage angel investments, while positioning the syndicate's social capital and network of women operators as door-opening power for founders.

• Deep interest in biotechnology and scientific innovation applied to human health and food systems. She frequently highlights portfolio companies like Helaina, which engineers yeast to produce human breast milk proteins, and Gameto, which focuses on female reproductive longevity.
• Prioritizes climate solutions and agricultural technology, often connecting these investments to her personal history. For instance, she related a deal involving Inner Plant and John Deere directly to her family's multi-generational background as farmland owners to emphasize the transformational potential for farmers.
• Strong advocacy for underrepresented founders and diversity within the venture capital ecosystem itself. She regularly posts about the All Raise summit and celebrates statistics regarding the growth of female fund managers and women-led teams.
• Focus on distinct, transformative technologies that update antiquated industrial systems. She has noted the massive opportunity in modernizing industrial processes built in the early 1900s and actively views decarbonization as a one hundred trillion dollar market opportunity.