Anna-Sofia Lesiv is a deep tech investor at Humba Ventures who combines full-time investing with being an active essayist and public thinker, running a Substack called "Second Nature" where she writes long-form pieces on topics like Moore's Law and the physical limits of computation. She also runs a recurring series called "How It's Built" that profiles how specific deep tech companies are actually engineered and manufactured, demonstrating a builder-level curiosity about physical systems and industrial processes rather than focusing only on markets and financial outcomes.

• A deep fascination with nuclear energy and highly ambitious physical engineering. There is a clear interest in both the historical and modern potential of atomic technology, referencing mid-century proposals to use atomic power for massive terraforming projects like excavating a new global canal. This translates to modern startup interests as well, shown by celebrating portfolio company Antares Nuclear for achieving the first critical reactor design in decades.
• A focus on advanced manufacturing, materials science, and hardware innovation. Attention frequently goes toward foundational engineering improvements that drastically increase efficiency, such as the evolving complexity of chip fabrication. One specific example is a strong enthusiasm for handheld laser welders that multiply power and speed exponentially, noting their direct application in major aerospace endeavors like Starship.
• An appreciation for elegant software design and eloquent storytelling in tech. There is a belief that the most imaginative digital pioneers succeed partly because they are excellent communicators and writers. This emphasis on thoughtful aesthetics also applies to daily software tools, demonstrated by using an artificial intelligence assistant to code a custom reading application just so it would match the visually refined theme of the note taking software Obsidian.
• Dedicated to supporting grassroots engineering and independent tinkerers. There is a strong affinity for self taught scientists and builders who operate outside traditional institutions, which is a core theme of the fellowship program run at Humba VC. A notable example of this appreciation is highlighting independent suppliers in the Midwest who literally draw complex superconducting wire in their basements to sell to advanced fusion companies.