Cecilia Manduca is a Principal at Talis Capital who focuses on the intersection of SynBio, climate tech, energy SaaS, mining & metals, TechBio infrastructure, and vertical social networks—an unusually cross-sector combination for an early-stage VC. She has rare recent operating experience, having left her VC role to serve as Chief of Staff at biotech software company Seqera and later took a leadership role at PortalOne, before returning to venture investing.
About their Fund
Sectors
Fintech, Cybersecurity, Data, SaaS, Health
Rounds
Seed - Series A
Avg Check Size
Notable Investments
Talis Capital evolved from a single-family office into a multi-family, private-wealth-backed VC platform that serves as an access point for over 30 families and high-net-worth individuals into top tech deals, with this family-office DNA shaping how they source capital differently from typical institutional-backed VCs. The fund is known as one of the earliest and highest-conviction backers of cyber-AI unicorn Darktrace, leading its Series A, which alongside other successes has given Talis an outsized reputation in AI and cyber relative to its fund size.
Other partners at the fund
Notable Fund
Investments
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Sheets they're in
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Sheets they're Fund is in
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Popular Investors
investor name
Active in
Rounds
Avg. Check
Links
Deeptech / Hardware
Robotics
Biotech
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12
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Unknown
Pre-Seed - Seed
Unknown
$400K - $2M
Unknown
Defense
Deeptech / Hardware
Energy
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7
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Unknown
Pre-Seed - Series A
Unknown
$100K - $5M
Unknown
Defense
Deeptech / Hardware
Energy
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7
View more in profile...
Unknown
Pre-Seed - Series A
Unknown
$100K - $5M
Unknown
Biotech
Health
Deeptech / Hardware
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2
View more in profile...
Unknown
Pre-Seed - Seed
Unknown
$250K - $2M
Unknown
Climate
Deeptech / Hardware
Materials
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4
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Unknown
Pre-Seed - Seed
Unknown
$400K - $1.5M
Unknown
Deeptech / Hardware
Robotics
Biotech
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7
View more in profile...
Unknown
Pre-Seed - Seed
Unknown
$400K - $2M
Unknown
Deeptech / Hardware
Robotics
Biotech
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2
View more in profile...
Unknown
Pre-Seed - Seed
Unknown
~$750K
Unknown
Fintech
Deeptech / Hardware
Devtools
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2
View more in profile...
Unknown
Pre-Seed - Series A
Unknown
$250K-$1M
Unknown
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