Isabella Fandrych focuses on energy, manufacturing, materials, and supply-chain infrastructure rather than climate broadly, backing technical teams that can scale hard science into real production and favoring methods already proven in adjacent industries over pure scientific novelty. She moved from advising German corporates at McKinsey to angel investing and then co-founded Nucleus Capital, building a portfolio spanning geothermal drilling, sustainable aviation fuel, copper extraction, battery supply chains, and direct air capture, and she is one of the named leaders behind an early KfW Capital commitment under Germany's Emerging Manager Facility as part of a gender-diverse fund leadership team.