Eric Lefkofsky is a serial entrepreneur-turned-investor who co-founded Groupon and founded Tempus, and he continues to actively run Tempus as CEO while serving as a general partner at Lightbank, giving him current operator experience that most VCs lack. He co-created Lightbank specifically to build the Chicago tech ecosystem rather than moving to a coastal hub after his success, and he focuses on data-driven businesses that can improve healthcare outcomes, drawing from his deep experience scaling AI and precision medicine companies.

• Championing the integration of artificial intelligence into clinical care to drive precision medicine. He emphasizes that technology must be foundational rather than adjacent to healthcare, illustrated by his company using AI to turn clinical data into real-time diagnostics for aggressive diseases like pancreatic cancer.
• Highlighting systemic inefficiencies and the urgent need to close care gaps where patients fall through the cracks. He points out specific statistics, such as the surprising fact that over ten percent of late-stage lung cancer patients at top centers are never tested for critical mutations, arguing that better data infrastructure is the solution.
• Advocating for comprehensive diagnostic approaches that go beyond standard testing. He frequently discusses the necessity of analyzing both tumor and normal DNA side-by-side to find true genetic drivers, as well as using RNA sequencing to better understand therapeutic responses in cancer treatment.
• A focus on scaling healthcare solutions through high-impact partnerships and acquisitions. He shares updates on collaborating with major academic medical centers like NYU Langone and Northwestern Medicine, and celebrates financial milestones like reaching over a billion dollars in revenue to prove the business model works.
• Promoting tools that put health insights directly into the hands of patients. He talks about deploying AI-driven assistants that allow individuals to navigate their own treatment journeys and carry their complete healthcare history with them, moving beyond just provider-facing tools.
• Celebrating entrepreneurial resilience and family achievements. Beyond sharing his track record of founding six companies that reached unicorn status, he frequently posts about his daughter's music releases, indicating he values personal support systems alongside professional success.