Isomer Capital is one of very few dedicated European VC fund-of-funds built specifically to back small, first-check, sub-€100m funds at scale, with over €600m AUM and ~70+ European VC relationships, acting as infrastructure LP to many of Europe's top emerging managers. The firm runs unusually deep regional research where they map ~90 funds down to 12 favorites and select only 3–4 based on return mechanics, diversification, and a partnership model demanding true two-way information sharing, while explicitly seeking managers with high Entrepreneurium—entrepreneurial energy and resilience—rather than emphasizing pedigree.