Digitalis Ventures operates as part of an integrated structure that includes a venture fund, a non-profit technology platform, and a research arm, allowing them to fund for-profit startups while building non-profit health infrastructure and working directly with government initiatives like ARPA-H. The firm built a distinctive franchise in animal health through its multi-hundred-million-dollar Companion Fund platform with Mars and takes a cross-category "health only" approach that spans human life sciences, health tech, and animal health under one umbrella.