John Josey is a venture capital investor at The Column Group who maintains an active scientific publishing career in medicinal chemistry while serving as a repeat biotech CEO, having led companies like Peloton Therapeutics from first employee to CEO through its acquisition by Merck. He has been repeatedly trusted by investor syndicates to build and lead successive oncology platform companies from the ground up, combining his PhD in organic chemistry with hands-on drug discovery experience and executive leadership across multiple successful exits.
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The Column Group
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Biotech, Health
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The Column Group operates as a venture ecosystem rather than a traditional VC fund, systematically creating single-drug biotech companies through its affiliated TCG Labs-Soleil engine instead of primarily backing existing startups. The fund has achieved documented outlier performance with a ~397% IRR on certain early-stage drug-discovery investments, distinguishing itself through deep scientific platform bets led by research-heavy leadership from the translational science community.
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