Josh Coyne co-hosts Kleiner Perkins' Grit podcast where he conducts detailed conversations with portfolio founders about product-market fit and go-to-market strategy, particularly for AI companies creating entirely new product categories. He focuses on backing technical teams building AI-native platforms that make complex workflows accessible to non-technical users, especially in areas where advanced AI can solve practical business problems for SMBs and everyday operators.

• Deep interest in artificial intelligence applied to specific vertical markets and enterprise functions. This includes a clear enthusiasm for startups that automate complex workflows in areas like accounting, construction permitting, and legal services, such as his support for Summation and their goal of redefining company operations through software.
• A focus on transforming the healthcare and biology sectors through technology. Tweets frequently highlight innovations in drug discovery and medical access, exemplified by his partnership with Garner Health to improve how patients navigate the system and his discussions on advanced topics like reversing aging and using computation to speed up medicine development.
• Appreciation for the tactical operations involved in scaling high-growth startups. He shares educational content aimed at helping founders navigate practical challenges, such as building modern finance teams or designing pricing models, while explicitly advising against pricing structures that rely solely on outcomes rather than usage or seats.
• Admiration for founders who display exceptional speed and distinct talent. He often praises teams that act as forces of nature or possess unique, polymathic abilities, citing the group at OpenEvidence as an example of people capable of reimagining major parts of the economy through relentless work.
• Investment in the infrastructure necessary to make automation and digital media scalable. This involves backing fundamental tools that allow artificial intelligence to operate securely within web browsers, like Browserbase, or platforms that enable mass generation of corporate video content, such as Synthesia.