Colle Capital Partners operates as a data-obsessed venture fund that requires "virtually all" deals to have an intrinsic relationship with data, while systematically pairing a small core team with an unusually deep bench of sector-specific advisors including CEOs, former executives from companies like Nike and Uber, and portfolio company founders who function as a distributed expert network. The female-founded, New York-based fund focuses on backing "infrastructure for complex, regulated or fragmented systems" across continents—from space-based solar power to Africa fintech rails to FDA-regulated medtech—while embedding sustainability as core investment criteria rather than a side theme.