Zach Weinberg is a serial founder who built and sold two companies—Invite Media to Google and Flatiron Health to Roche for $1.9-2.1B—before becoming a full-time investor at Operator Partners, which he runs using only his own capital without outside investors. He simultaneously operates as both a venture investor and CEO of Curie.Bio, a platform that combines biotech funding with hands-on company-building, while specializing in health and biotech data companies.

• Deep interest in market incentives and economic principles, frequently arguing that behavior flows directly from financial structures—whether that involves creating proper rewards for developing new antibiotics or warning that wealth taxes often cause high-net-worth individuals to leave a country.
• A focus on operational efficiency and fiscal responsibility, often drawing parallels between government budgets and startup management; implies that public leaders should demonstrate clear results and efficiency with existing funds before requesting more money, much like a founder must do with investors.
• Valuing high-quality questions during the hiring process, noting that the best startup employees are those who dig deep, ask clarifying questions, and push for second or third-order understanding rather than just accepting a surface-level explanation.
• Strong advocacy for the New York tech ecosystem, frequently suggesting that state leadership should aggressively recruit technology headquarters away from California to build the local tax base and warning against policies that drive capital away from the city.
• Interest in the intersection of healthcare and regulation, specifically criticizing companies that appear to exploit regulatory loopholes—such as compounding pharmacies abusing shortage exceptions—while simultaneously calling for better legislative support for critical medical advancements.
• Belief in the productivity-multiplying power of AI, suggesting that new tools will make smart, hard-working individuals significantly more effective while potentially raising the baseline intelligence required to be economically useful in the future workforce.
• Support for supply-side economic solutions, particularly regarding housing and goods; consistently argues that the best way to lower prices is to remove regulatory roadblocks and build more supply rather than implementing price controls or subsidies.
• A positive view on the developmental benefits of video games, arguing that—within reasonable time limits—gaming helps children develop strategic thinking, planning skills, and social connections.