Samir Kaul is a Founding Partner at Khosla Ventures who personally led the firm's very early, outsized bet on OpenAI, cutting what's been described as the first and largest check into the company at the time. He started his career in genomic sciences at Craig Venter's Institute for Genomic Research before moving into business, giving him hands-on genomics experience that he brings to evaluating complex biotech, health, and deep-tech companies.
What they've been talking about across their social media accounts

- Deep loyalty to the University of Michigan, spanning from celebrating football championships to funding major academic initiatives like a new institute for AI at the school.
- Personal dedication to health optimization and sleep fitness, frequently posting his own recovery statistics from devices like Whoop and Eight Sleep to show how the tech improves his daily life.
- Focus on long-term partnerships with repeat founders, exemplified by his pride in backing entrepreneur Gilad Almogy across four different companies and investing in the startup of a former Chief of Staff to Keith Rabois.
- Strong appreciation for food innovation and sustainability, specifically highlighting the rollout and health certifications of plant-based products like Impossible Foods.
- Enjoyment of camaraderie and playful rivalry with fellow investors, most notably engaging in public bets and friendly roasting of Keith Rabois regarding sports outcomes.
- Active involvement in philanthropy and academic endowments, such as supporting World Central Kitchen's relief efforts and funding joint medical professorships between Harvard Medical School and Harvard Business School.
About their Fund
Sectors
AI, Health, Climate, Enterprise, Biotech
Rounds
Seed - Series B+
Avg Check Size
$500K - $50M
Notable Investments
Khosla Ventures is led by Sun Microsystems founder Vinod Khosla, who explicitly optimizes for ~70% failure rates to back "black swan" outcomes and actively seeks opportunities that appear "crazy" to most of the market through non-consensus thinking. The firm focuses on extreme technical risk while avoiding conventional market risk, backing capital-intensive, science-heavy bets across climate, healthcare, and deep tech that software-focused funds historically avoided, with Khosla positioning the firm as a vehicle for aggressive techno-optimism to drive radical societal change.
Other partners at the fund
Notable Fund
Investments
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Avg. Check
Links
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